ROXY Peptide Cleavage

ROXY Peptide Cleavage System

Rapid Peptide Cleavage with Electrochemistry
 
Proteins cleave at specific amino acids when subject to an electric current under the correct buffer conditions.
Cleavage occurs specifically at Tyrosine and Tryptophan and so the outcome of electrochemical oxidation is predictable and controllable.
It is also extremely rapid, opening the possibility of on-line, automatable peptide mapping.
 
 
ROXY EC/LC-MS System
The image to the right shows the cleavage profile of alpha-lactalbumin under oxidative electrochemical conditions. The ROXY system allows this types of cleavage to be performed on-line to MS, resulting in a higher level of automation and more rapid analysis.
 
 
Electrochemical Oxidation of Lactalbumin
Hjalmar P. Permentier, Andries P. Bruins, 2003
To download a ROXY brochure click here
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