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| Michrom Bioresources' Axial Desolvation Vacuum Assisted Nano Capillary Electrospray (ADVANCE™) source uses CaptiveSpray™ technology for high sensitivity and high throughput LCMS. CaptiveSpray couples a LC column through a capillary spray tip to the inlet of the MS, such that a vacuum seal is created and air is pulled in and around the spray tip . |
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| An air funnel sweeps the spray tip and desolvates the sample ions as they are pulled into the MS, which allows faster LC flows and higher sample loading, resulting in higher sensitivity and/or significantly shorter run times. The capillary spray tip is a 30µ ID by 90µ OD Fused Silica Tube (no tapering), which is not susceptible to the plugging, fouling or degradation that effects most tapered NanoSpray tips. |
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| For trace level analysis, the CaptiveSpray source can pull in high purity air, rather than lab air (as in NanoSpray), enhancing signal to noise by eliminating background ions from the ambient air environment. |
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